In silico investigation of molecular interactions of volatile anesthetics: effects on phospholipid membranes and subcellular targets

Authors

  • Eric A. Zizzi PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin
  • Marco Cavaglià PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin
  • Marco A. Deriu PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin
  • Jack A. Tuszynski PolitoBIOMedLab, Department of Mechanical and Aerospace Engineering, Politecnico di Torino, Turin

DOI:

https://doi.org/10.4081/bse.202

Keywords:

Anesthetics, molecular dynamics, membrane, phospholipids, microtubules

Abstract

The ability of anesthetics to reversibly suppress consciousness must reside in the effects exerted onto specific molecular targets. Interactions between volatile anesthetics and the phospholipid membrane as well as intracellular tubulin, were investigated using Computational Molecular Modelling, which showed rapid ligand partitioning inside the membrane and significant effects on the mechanical characteristics thereof, while transient binding locations have been found on the tubulin dimer.

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Published

29-09-2021

Issue

Vol. 2 No. 1 (2021)

Section

Communications

License

Copyright (c) 2021 The Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

How to Cite

In silico investigation of molecular interactions of volatile anesthetics: effects on phospholipid membranes and subcellular targets. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.202