Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver

Authors

  • Giuseppe Guagliano Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan
  • Manuela Legnardim Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan
  • Cristina Volpini Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia
  • Nora Bloise Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia
  • Silvia Dotti National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, Brescia
  • Riccardo Villa National Reference Center for Alternative Methods, Welfare and Care of Laboratory Animals, Istituto Zooprofilattico Sperimentale della Lomabardia ed Emilia Romagna, Brescia
  • Livia Visai Molecular Medicine Department (DMM), Center for Health Technologies (CHT), UdR INSTM, University of Pavia, Pavia; Medicina Clinica-Specialistica, UOR5 Laboratorio di Nanotecnologie, ICS Maugeri, IRCCS Pavia
  • Paola Petrini Department of Chemistry, Materials and Chemical Engineering “Giulio Natta”, Politecnico di Milano, Milan

DOI:

https://doi.org/10.4081/bse.172

Keywords:

Hepatotoxicity, in vitro models, 3D models, alternative models

Abstract

Drug development is a high failure rate process; too many drugs fail during clinical trials because of severe hepatotoxicity. This situation can be significantly improved by redesigning preclinical trials, and privileging the use of high-throughput in vitro models, by combining cell-based in vitro models and material-based models.

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Published

29-09-2021

Issue

Vol. 2 No. 1 (2021)

Section

Communications

License

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

How to Cite

Drug-induced hepatotoxicity studied in a 3D, in vitro model of the liver. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.172