Towards reliable in vitro models. New bi-compartmental platforms for replicating tissue barriers

Authors

  • Lorenzo P. Coppadoro Department of Electronics, Information and Bioengineering, Politecnico di Milano
  • Elia Pederzani Department of Electronics, Information and Bioengineering, Politecnico di Milano
  • Chiara Foglieni Cardiovascular Research Area, IRCCS San Raffaele Scientific Institute, Milano
  • Maria Lombardi Cardiovascular Research Area, IRCCS San Raffaele Scientific Institute, Milano
  • Gianfranco B. Fiore Department of Electronics, Information and Bioengineering, Politecnico di Milano
  • Monica Soncini Department of Electronics, Information and Bioengineering, Politecnico di Milano

DOI:

https://doi.org/10.4081/bse.166

Keywords:

Cell cultures, laser cutting, bicompartmental, reuse, in vitro tissue models, tissue barriers

Abstract

In vitro cell cultures represent a widespread methodology for pathophysiology studies with a high benefit/cost ratio. We have developed and are validating TToP, a novel, versatile, and scalable culture system allowing compartmentalized cell/tissue cultures with the aim of mimicking the human pathophysiological microenvironment of tissue barriers.

Downloads

Download data is not yet available.

References

Paul SM, Mytelka DS, Dunwiddie CT, et al. How to improve R&D productivity: the pharmaceutical industry's grand challenge. Nat Rev Drug Discov 2010;9:203-14.

Astashkina A, Mann B, Grainger DW. A critical evaluation of in vitro cell culture models for high-throughput drug screening and toxicity. Pharmacol Ther 2012;134:82-106.

Walsh III D.I. Kong DS, Murthy SK, Carr PS. Enabling Microfluidics: from Clean Rooms to Makerspaces. Trends Biotechnol2017;35:383-92.

Ren Y, Ray S, Liu Y. Reconfigurable Acrylic-tape Hybrid Microfluidics. Sci Rep. 2019;9:4824.

Downloads

Published

29-09-2021

Issue

Vol. 2 No. 1 (2021)

Section

Communications

License

Copyright (c) 2021 The Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

How to Cite

Towards reliable in vitro models. New bi-compartmental platforms for replicating tissue barriers. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.166