Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma in vitro cultured

Authors

  • Deyanira Contartese Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Francesca Salamanna Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Veronica Borsari Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Stefania Pagani Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Maria Sartori Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Lucia Martini Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Giovanni Barbanti Brodano Spine Surgery Prevalently Oncologic and Degenerative, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Alessandro Gasbarrini Spine Surgery Prevalently Oncologic and Degenerative, IRCCS Istituto Ortopedico Rizzoli, Bologna
  • Milena Fini Complex Structure of Surgical Sciences and Technologies, IRCCS Istituto Ortopedico Rizzoli, Bologna

DOI:

https://doi.org/10.4081/bse.165

Keywords:

Bone metastasis, breast carcinoma, ex vivo model

Abstract

Breast cancer frequently metastasizes to the skeleton causing significant morbidity. Here, we set-up a novel and advanced ex vivo model by using fresh tissue from human vertebral bone metastasis from breast carcinoma patients able to retain the tumor microenvironment and tumor cells heterogeneity.

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Published

29-09-2021

Issue

Vol. 2 No. 1 (2021)

Section

Communications

License

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

How to Cite

Development and characterization of a novel human 3D model of bone metastasis from breast carcinoma in vitro cultured. (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.165