Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells

Authors

  • Danila Cianciosi Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy
  • Lucia Regolo Department of Clinical Sciences, Polytechnic University of Marche, Ancona
  • Maurizio Battino Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy; International Research Center for Food Nutrition and Safety, Jiangsu University, Zhenjiang
  • Francesca Giampieri Department of Clinical Sciences, Polytechnic University of Marche, Ancona, Italy; Department of Biochemistry, Faculty of Sciences, King Abdulaziz University, Jeddah

DOI:

https://doi.org/10.4081/bse.163

Keywords:

5-Fluoruracil, cancer, honey, spheroids, stemness

Abstract

Manuka honey (MH) has an in vitro chemosensitizing effect against 5-Fluorouracil (5-Fu) in colonspheres enriched with cancer stem (-like) cells (CSCs-like); these interesting findings, although preliminary, suggest a potential synergistic action of MH with 5-Fu, which could be useful in deepening the studies on natural compounds to be used in association with conventional medical therapies.

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Published

29-09-2021

Issue

Vol. 2 No. 1 (2021)

Section

Communications

License

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

How to Cite

Effect of manuka honey on 5-fluorouracil chemosensitivity in colonspheres enriched with cancer stem (-like) cells . (2021). Biomedical Science and Engineering, 2(1). https://doi.org/10.4081/bse.163