How systems biology of cancer signaling pathways can inform optimized combination chemotherapy design

Authors

  • Jack A. Tuszynski DIMEAS, Politecnico di Torino, Torino, Italy; Department of Physics, University of Alberta, Edmonton, Canada
  • Edward A. Rietman Department of Computer Science, University of Massachusetts, Amherst

DOI:

https://doi.org/10.4081/bse.143

Keywords:

Systems biology, protein-protein interactions, network analysis, cancer signaling networks, Gibbs free energy, protein expression

Abstract

This talk presents an overview of the systems biology of cancer applied to specific protein-protein interaction signaling pathways. We argue that network analysis augmented with thermodynamics measures such as Gibbs free energy can lead to optimized design of drug combinations for cancer chemotherapy.

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Published

29-09-2021

Issue

Vol. 3 No. 1 (2022)

Section

Original articles

License

Copyright (c) 2021 The Authors

Creative Commons License

This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

PAGEPress has chosen to apply the Creative Commons Attribution NonCommercial 4.0 International License (CC BY-NC 4.0) to all manuscripts to be published.

How to Cite

How systems biology of cancer signaling pathways can inform optimized combination chemotherapy design. (2021). Biomedical Science and Engineering, 3(1). https://doi.org/10.4081/bse.143